A Case of Becker's Nevus Associated with Ipsilateral Breast Hypoplasia / 대한피부과학회지

We report a case of Becker's nevus associated with ipsilateral breast hypoplasia in a 13-year-old female. Three years esrlier, she noticed a palrn-size hyperpigmented area on her left chest. The lesion showed a well defined geographic border. No hypertrichosis was seen. Hypoplasia was apparent on the left breast. A histopathologic finding showed a slightly hyperpigmented epidermis and some rectangular rete ridges with flat bases.

Clinical and Histopathologic Features of Pernio / 대한피부과학회지

BACKGROUND: Pernio or chilblain is an abnormal reaction to damp cold air, resulting in pruritic erythematous swellings on acral skin. The histologic features are subepidermal edema, diffuse fluffy edema of endothelial cell, and superficial or superficial and deep perivascular lymphocytic infiltrates. Many studies with a large sample size have been conducted in western countries, but there were no collective studies of pernio that have been reported in Korea. OBJECTIVE: The purpose of this study was to clarify the clinical and histopathologic features of pernio in Korea. METHODS: We reviewed the clinical and histopathologic findings in ten patients with pernio who visited the Department of Dermatology, Kosin Medical College Gaspel Hospital during the 10 year period from 1988 to 1997. RESULTS: The results were as follows.1. The age distribution was in the range of 6-50 year old. The prevalance was heighest in the third and fourth decade. Sex ratio was 1:4 (2 males :8 females).The duration of symptoms ranged from 4 days to 30 years. All patients developed skin lesions on the acral area. Two male patients developed skin lesions on the hand associated with cold exposure and outdoor works. All patient had itching and burning papules and/or plaques, and one had a painful hard nodule. Laboratory studies were all negative and within normal ranges.2. Histopathologic features revealed subepidermal edema, diffuse fluffy edema of endothelial cell, and superficial or superficial and deep perivascular lymphocytic infiltrates in all specimens. 3. Treatment includes prophylatic measures against cold and nifedipine(calcium channel inhibiting drug). In more severe cases, pentoxifylline might be helpful. CONCLUSION: Our study suggests that pernio commonly occurs in twenty to forty year old females during fall and winter. Upon exposure to cold temperatures, the acral skin develops pruritic erythematous papules and plaques. If these lesions persisit for a long time or recur, they may progress to vesicle and ulceration and possibly develop vasculitis which does not respond to therapy well. Thus, a thorough understanding of clinical and histopathologic features of pernio is vital in making a diagnosis, a treatment plan and determining the prognosis.

Successful Treatment of Mucosal Melanosis of the Lip with Q-switched Alexandrite Laser / 대한피부과학회지

Mucosal melanosis such as labial and vulvar pigmented macules is common as well as cosmetically disfiguring benign pigmented lesions. Until the recent development of laser treatments, it was impossible to remove a mucosal melanosis without leaving a scar. The Q-switched Alexandrite laser, which has a wavelength of 755 nm and a short pulse duration of 100 nanoseconds, has been used for the treatment of dermal pigmentary disorders such as Nevus of Ota and tattoos. We treated two patients with labial melanosis by the Q-switched Alexandrite laser using a 2,4 mm spot size and energy fluences of 4.5 to 7 J/cm2. Their mucosal pigmentations were completely cleared without adverse sequelae or recurrence after one session of the treatment. We report that Q-switched Alexandrite laser might be a highly effective and safe modality for the treatment of mucosal melanosis and suggest it as the treatment of choice.

A Case of Spindle Cell Lipoma / 대한피부과학회지

Spindle cell lipoma was first described in 1975 by Enzinger and Harvey as a variant of lipomas. Histopathological findings show the lipomatous tissue to be replaced by a mixture of uniform spindle cells and mature fat cells closely associated with a mucoid matrix and a varying number of collagen fibers. Immunohistochemical staining is reported to give assistance in the differential diagnosis af spindle cell lipoma from other fibrous or neural tumors. Also, it can be used to investigate the origin of the spindle cells. We report a case of spindle cell lipoma in a 41-year-old female. She had a solitary, normal skin colored, bean sized, subcutaneous mass on the forearm. Most of the spindle cells were strongly positive for vimentin, CD34 and NSE, but negative for actin, factor VIII, S-100 protein and neuro- filaments. The tumor was excised. No recurrence was recognized in a 10 month follow up period.

Clinical and histopathological studies on ovarian tumors / 대한산부인과학회잡지

No abstract available.